{"id":12163,"date":"2024-02-14T19:54:20","date_gmt":"2024-02-14T19:54:20","guid":{"rendered":"https:\/\/alehlatam.org\/wp2024\/?page_id=12163"},"modified":"2024-12-20T12:27:58","modified_gmt":"2024-12-20T15:27:58","slug":"hepatotoxicidad","status":"publish","type":"page","link":"https:\/\/alehlatam.org\/en\/investigacion-educacion\/grupos-de-interes\/hepatotoxicidad\/","title":{"rendered":"Hepatotoxicity"},"content":{"rendered":"
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A little bit of history<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The project to generate a Hepatotoxicity Registry in our continent was born as an initiative of the Spanish hepatotoxicity group, the Spanish DILI Registry<\/a>, led by Maribel Lucena and Ra\u00fal J Andrade, in the framework of the international DRUG-Induced Liver Injury Consortium (IDILIC), an international non-profit consortium composed of academic institutions, regulatory agencies and the pharmaceutical industry.<\/p>\n

Latin America was not represented and at the of 2011, the Spanish DILI Registry<\/a> offered us to join and share its experience to achieve a methodological training and guide us in the creation of national networks by identifying a coordinator in each country to centralize the identification and characterization of cases of hepatotoxicity in its area of influence. Dr. Fernando Bessone was chosen as coordinator of the Latin American group because of his recognised professional and scientific career in this field of hepatology. We have started to consolidate and gradually generate the database of the Latin American DILI Registry (LATINDILI Registry).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Who we are<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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We are a registry that includes several countries. Argentina, Brazil, Chile, Ecuador, Mexico, Paraguay, Peru, Venezuela and Uruguay are the countries that have joined and submitted cases. We have come together regardless of the many differences that characterize us in terms of geographical area, population size, local epidemiology of the different liver diseases to be excluded, drug prescription policies, culture in the use of herbs, etc.. We have come together with a common goal, sharing information generously, learning from those who have traveled this road before, and making these differences our virtue.\u00a0www.slatindili.uma.es<\/a>\u00a0and we invite you to visit it. There you will be able to access all the information about the group, such as the meetings we have held (in person and online), photos of the team, and the publications we have made during these 10 years of work.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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How do we work?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Based on\u00a0standardized criteria<\/a>\u00a0to diagnose and classify liver toxicity in the context of the Registry. Once it is suspected that the liver disease in study could be a consequence of a toxicity,\u00a0standardized protocol<\/a>\u00a0is completed and reviewed by the coordinator of each country, or the coordinator of the registry or the coordinators of the Spanish registry in the event that there is not yet a physician acting as a centralizer in that country. The main task of the reviewer is to verify that the case meets the requirements to be considered as probable hepatotoxicity and that the information uploaded is as complete as possible. Once the coordinator reviews it, it is then sent to the coordinating center in Spain where it goes through a second review and expert opinion to define it and be uploaded to the database.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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ALEH and the registry<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The Latin American Association for the study of the Liver has generated and encouraged the formation of interest groups and among them is the hepatoxicity group.<\/strong>.<\/p>\n

At the Congress in Santiago (2016), we had the first meeting within the framework of ALEH. Representatives from 7 countries were present and we were able to discuss the experience that each member has had. We also have made special emphasis on those difficulties that we have found in practice according to the local reality and what solutions there are.\u00a0link you can access the minutes of the meeting and the photos<\/a>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Publications<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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We have included some of the group's publications, which we hope will be an additional incentive for other groups from Latin America to join us.<\/p>\n